Relationship between interferon⁃γ induced monocyte level and coronary slow flow phenomenon
10.19405/j.cnki.issn1000-1492.2023.01.027
- Author:
Youfeng Liang
1
;
Zeng Guo
1
;
Yiming Zhang
1
;
Chunmiao Wang
1
;
Baoshan Cheng
1
;
Feng Liang
1
Author Information
1. Dept of Cardiology, The First Afiliated Hospital of Anhui Medical University, Hefei 230001
- Publication Type:Journal Article
- Keywords:
chemokine;
MIG;
coronary slow flow;
coronary artery disease
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between monokine induced by interferon⁃gamma (MIG) level and coronary slow flow phenomenon ( CSFP) .
Methods:80 patients diagnosed with CSFP and 54 patients with normal CAG were selected as the CSFP group and no⁃CSFP group respectively in this study. Coronary slow flow was determined quantitatively by thrombolysis in myocardial infarction (TIMI) frame count (TFC) method. The clinical characteristics and biochemical indexes , including serum CD40L and Interferon⁃γ (IFN⁃γ) , monokine induced by interferon⁃gamma (MIG) levels were measured , and the relationship between interferon⁃γ induced monocyte level and CSFP were analyzed.
Results:The serum levels of CD40L , IFN⁃γand MIG in the CSFP group were higher than those in the no⁃CSFP group ( P = 0. 001) . The MIG levels were positive correlated with mean TFC ( r =0. 879 ,P = 0. 009) . Multivariate logistic regression analysis showed that MIG was an important risk factor for CSFP (β = 0. 874 ,P = 0. 011) . The ROC curve analyses indicated that the MIG levels had diagnostic value in patients with CSFP , the area under the curve ( AUC) was 0. 793 , the sensitivity was 0. 79% and the specificity was 76. 0% , and 95% CI 0. 714 - 0. 872.
Conclusion:Chemokine CD40L , IFN⁃ γ and MIG may be involved in the process of vascular inflammation and arteriosclerosis. MIG is an important influencing factor of CSFP and participated in the occurrence and development of CSFP.
- Full text:202407131152116141干扰素-γ诱导的单核因子与冠脉慢血流现象关系研究_梁有峰.pdf
