Associated factors of peripheral blood lymphocyte counts in gastric cancer : a cross⁃sectional study
10.19405/j.cnki.issn1000-1492.2023.01.025
- Author:
Shengyi Wang
1
;
Hao Zhou
2
,
3
;
Hu Liu
4
Author Information
1. Dept of General Surgery, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
2. Dept of Surgery,901th Hospital of the Chinese People &prime
3. s Liberation Army Joint Logistics Support Force , Hefei 230031
4. Dept of Oncology, West District of The First Afiliated Hospital of University of Science and Technology of China ,Hefei 230031
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
peripheral blood lymphocyte count;
multiple linear regression;
cross⁃sectional study;
locally weighted regression;
robust linear model;
TNM staging
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the associated factors of peripheral blood lymphocyte counts (PBLC) in gastric cancer patients
Methods:In this cross⁃sectional study , data were collected from patients underwent gastric cancer surgery. Univariate analysis , multiple linear regression and variable importance metrics were used to assess factors associating PBLC in pre⁃operative patients. The findings were further investigated by fitting locally weighted regression(loess) and robust linear model (rlm) .
Results:Patients with pre⁃operative PBLC < 1 . 1 × 109/L( group A) were 138(20. 72% ) , whereas patients with PBLC ≥ 1. 1 × 109/L ( group B) were 528(79. 28% ) . Compared to group B , patients in group A were older[(64. 61 ± 10. 42 years) vs (62. 18 ± 10. 41 years) , P < 0. 05 ] and showed lower neutrophils [(3. 21 ± 1. 41) × 109/L vs (3. 59 ± 1. 31) × 109/L , P < 0. 01] . Lymphopenia was associated with later stage of gastric cancer, P < 0. 01 . A multiple linear regression model with randomly distributed residuals found that age ( β = - 0. 01 , t = - 3. 70 , P < 0. 01) and tumor stage [ β ( Ⅱ vs Ⅰ ) = - 0. 16 , t =- 2. 79 , P < 0. 01 ; β ( Ⅲ vs Ⅰ ) = - 0. 18 , t = - 3. 86 , P < 0. 01 ; β ( Ⅳ vs Ⅰ ) = - 0. 21 , t = - 2. 16 , P <0. 05] were to be statistically significant factors for lymphopenia. Neutrophil increase (β = 0. 05 , t = 3. 61 , P < 0. 01) was associated with a higher PBLC. The relative importance analysis for continuous independent variables showed that relative importance metric LMGs in variable age , neutrophil and CEA were 55. 55% , 44. 14% and 0. 31% respectively. Loess and rlm models showed that age was the negatively influencing factor of PBLC.
Conclusion:PBLC in gastric cancer patients were positively associated with neutrophils , and negatively associated with age and tumor stages.
- Full text:2024071222055772312胃癌外周血淋巴细胞数关联因素的横断面研究_汪圣毅.pdf
