Association analysis between SNPs in VGLL4 gene and Helicobacter pylori infection
10.19405/j.cnki.issn1000-1492.2023.01.019
- Author:
Xia Yang
1
;
Wenjie Dong
1
;
Jinbao Wu
2
;
Licong Ma
2
;
Xianmei Meng
2
;
Fang Gao
3
;
Yanbin Jia
4
,
5
Author Information
1. School of Basic Medicine and Forensic Medicine ,The Second Afiliated Hospital of Baotou Medical College , Baotou 014030
2. Inner Mongolia Institute of Digestive Diseases , The Second Afiliated Hospital of Baotou Medical College , Baotou 014030
3. School of Medical Technology and Anesthesiology,The Second Afiliated Hospital of Baotou Medical College , Baotou 014030
4. School of Basic Medicine and Forensic Medicine ,Inner Mongolia Institute of Digestive Diseases ,The Second Afiliated Hospital of Baotou Medical College , Baotou 014030
5. School of Nursing , Baotou Medical College ,Baotou 014060
- Publication Type:Journal Article
- Keywords:
vestigial like family member 4;
single nucleotide polymorphism;
Helicobacter pylori;
genetic suscep⁃ tibility
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the associations between the single nucleotide polymorphism(SNP) in vestigial like family member 4(VGLL4) gene and Helicobacter pylori(H. pylori) infection.
Methods:The blood samples of 450 normal physical examiners were collected , and the samples were divided into H. pylori negative group( n =220) and H. pylori positive group(n = 230) using enzyme⁃linked immunosorbent assay(ELISA) . SNP rs1803489 ,rs7617620 , and rs13078528 in VGLL4 gene were genotyped using polymerase chain reaction ( PCR) Ⅳrestriction fragment length polymorphism ( RFLP) technology.
Results:SNP rs1803489 , rs7617620 , and rs13078528 in VGLL4 gene were not associated with H. pylori infection in the Han population in Baotou , Inner Mongolia.
Conclusion:SNP rs1803489 , rs7617620 , and rs13078528 in VGLL4 gene may not play a major role in H. pylori infection in Baotou Han population.
- Full text:2024071219031510731VGLL4基因多态性与幽门螺杆菌感染的关系_杨霞.pdf
