Study on the mechanism of FAK⁃PI3K/AKT signal pathway in the growth and development of neonatal rat cranial bone
10.19405/j.cnki.issn1000-1492.2023.01.018
- Author:
Sixi Zhang
1
;
Xiaolu Zhang
2
;
Lei Wang
2
;
Yubo Ma
3
;
Guo Shao
4
;
Chunyang Zhang
2
Author Information
1. Baotou Medical College ofInner Mongolia University of Science and Technology Baotou 014010
2. Dept of Neurosurgery, The First Afiliated Hospital of Baotou Medical College ofInner Mongolia University of Science and Technology,Baotou 014010
3. Dept ofEndocrinology, The Third Hospital of Qinhuangdao , Qinhuangdao 066000
4. Translational Medicine Center, Third People Hospital of Longgang District , Shenzhen 518100
- Publication Type:Journal Article
- Keywords:
cranial bone;
FAK;
PI3K/AKT;
growth and development
- From:
Acta Universitatis Medicinalis Anhui
2023;58(1):109-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the growth characteristics of rat calvaria by detecting the calvaria of SD rats in different periods.
Methods:The calvaria of SD rats at 1 , 4 , 7 , 10 , and 12 weeks from the same littermate were selected (3 rats per week) . Real⁃time PCR and Western blot techniques were used to detect the expression of focal adhesion kinase ( FAK) Ⅳ phosphatidylinositol 3 kinase/protein kinase B ( PI3K/AKT ) signal pathway in the calvaria , and the role of FAK⁃PI3K/AKT in the growth and development of the calvaria was analyzed by correlation.
Results:The increase of brain volume and the thickness of calvaria increased synchronously , the expression of FAK was positively correlated with the changes of meridians , and the expression of FAK was positively correlated with the expression of PI3K/AKT.
Conclusion:The expression of FAK is related to the growth and development of rat skull. FAK plays a role in calvaria by activating PI3K/AKT signal pathway. FAK may be used as a marker of rapid skull growth and development , which provides a basic theoretical basis for the timing of clinical skull defect repair and treatment.
- Full text:202407121853493961FAK-PI3K_AKT信...长发育过程中作用机制的研究_张司玺.pdf
