The role of IL-22 / STAT3 pathway in insulin resistance caused by intermittent hypoxia
10.19405/j.cnki.issn1000-1492.2023.10.012
- Author:
Hongfei Liu
1
;
Tingting Sun
1
;
Jiahui Tian
1
;
Xinjie Chen
1
;
Lijue Ren
1
;
Jing Du
1
;
Fang Han
2
,
3
;
Cuiying Wei
2
,
3
Author Information
1. Dept of Inner Mongolia University of Science and Technology，The First Affiliated Hospital of Baotou Medical College，Baotou 014010
2. Sleep Medicine Center，Peking University People '
3. s Hospital，Beijing 100044
- Publication Type:Journal Article
- Keywords:
chronic intermittent hypoxia;
insulin resistance;
interleukin-22;
STAT3
- From:
Acta Universitatis Medicinalis Anhui
2023;58(10):1678-1682
- CountryChina
- Language:Chinese
-
Abstract:
Objective : By observing the changes of interleukin-22 ( IL-22) ，signal transduction and transcriptional activator 3 (STAT3) ，fasting blood glucose ( FBG) and fasting insulin ( FINS) of rats under the circumstance of chronic intermittent hypoxia and reoxygenation，to explore the role of IL-22 / STAT3 pathway in insulin resistance in- duced by chronic intermittent hypoxia．
Methods :4 SD rats were randomly divided into control group (NC group) and intermittent hypoxia group ( CIH group) ，with 12 rats in each group．NC group was placed in normoxia environment for 12 weeks，while CIH group was first given intermittent hypoxia for 8 weeks and then resumed normoxia feeding until 12 weeks．FBG，FINS，IL-22 and p-STAT3 / STAT3 levels were measured at baseline，week 8 and week 12 in both groups，and insulin resistance index (HOMA-IR) was calculated．The differences between the two groups were compared.
Results :① There was no significant difference of the observation indexes between the two groups at baseline (P＞0. 05) ．At 8 weeks，the levels of FBG，FINS and HOMA-IR in CIH group were higher than those in NC group (P＜0. 05) ，and the levels of IL-22 were lower than those in NC group (P ＜0. 05) ．p-STAT3 / STAT3 showed a decreasing trend，but not statistically significant．At 4 weeks of reoxygenation，there were no significant differences in FBG，FINS，HOMA-IR and IL-22 levels between the two groups (P ＞0. 05 ) ．p-STAT3 / STAT3 in CIH group was significantly higher than that in NC group ( P ＜0. 05 ) . ② Spearman rank correlation analysis showed that HOMA-IR was negatively correlated with IL-22 and p-STAT3 / STAT3 ( all P ＜0. 05) ．
Conclusion:Chronic intermittent hypoxia can inhibit the expression of IL-22 / STAT3 signaling pathway，IL-22 / STAT3 signaling pathway may mediate insulin resistance induced by chronic intermittent hypoxia.
- Full text:2024071218202507393IL-22_STAT3信号...歇低氧致胰岛素抵抗中的作用_刘宏飞.pdf
