Interplay of interleukins (IL6, IL10) and 25 hydroxycholecalciferol in asthmatic subjects with chronic post-COVID condition (PCC)
https://doi.org/10.47665/tb.41.1.009
- Author:
Jaleel, A.
1
;
Namoos, K.
1
;
Asim, S.
1
;
Uppal, S.S.
1
;
Zaman, S.
1
;
Irfan, H.
1
;
Pervaiz, S.
1
;
Tariq, M.
1
;
Shafique, M.
1
Author Information
1. Shalamar Medical and Dental College, Shalimar Link Road Mughalpura, Lahore, Pakistan
- Publication Type:Journal Article
- Keywords:
Asthma;
post-COVID condition (PCC);
interleukin 6;
interleukin 10;
25-hydroxycholecalciferol.
- From:Tropical Biomedicine
2024;41(No.1):70-77
- CountryMalaysia
- Language:English
-
Abstract:
The study aimed to compare and correlate serum levels of IL-6, 10, and 25-hydroxycholecalciferol
in individuals with asthma with and without post-COVID condition (PCC). The study was designed
to investigate the inflammatory response and serum 25-hydroxycholecalciferol status in asthmatics
with and without PCC. A cross-sectional study of 252 subjects (128 asthmatics and 124 non-asthmatic
subjects) was carried out. Interleukins and 25-hydroxycholecalciferol levels were estimated on ELISA.
The principle findings were that IL-6 and 25-hydroxycholecalciferol levels were significantly increased
(p<0.001), while IL-10 levels were non-significant in asthmatics with PCC compared to those without PCC.
However, 25-hydroxycholecalciferol levels were significantly increased, but no significant change was
observed in IL-6, and IL-10 levels in non-asthmatics with and without chronic PCC. A significant positive
correlation (r = 0.258) was found between 25-hydroxycholecalciferol and IL-6 but a significant negative
correlation (r = -0.227) with IL-10 in asthmatics with PCC. Similarly, a significant negative correlation (r
= -0.285) was found between 25-hydroxycholecalciferol and IL-10 but was non-significant with IL-6 in
asthmatics without PCC. The correlation of 25-hydroxycholecalciferol with IL-10 was significant (0.683),
but IL-6 was non-significant in non-asthmatics with PCC. Multiple regression analysis showed that age,
IL-6, gender, and PCC were significantly related in adjusted values to 25-hydroxycholecalciferol. This
study sheds light on the complex liaison between 25-hydroxycholecalciferol levels and inflammatory
responses in asthmatics, especially those with PCC. The findings suggest that although asthmatics with
PCC maintain sufficient levels of 25-hydroxycholecalciferol, they show a substantial increase in the proinflammatory response. This suggests that PCC exacerbates the pro-inflammatory response in asthma.
Moreover, the study reveals that asthmatics, whether with or without PCC, display a negative correlation
between 25-hydroxycholecalciferol and the anti-inflammatory response. This emphasizes the main
influence of asthma on the overall inflammatory response. These findings reveal a complex interplay
between vitamin D levels and inflammatory mediators in asthmatic individuals with and without PCC.
- Full text:20240711163742836148.2024my1455.pdf
