Analysis of prognostic factors of gastric cancer patients with liver metastases and establishment of a nomogram for survival prediction
10.3969/j.issn.1673-9701.2024.12.002
- VernacularTitle:胃癌肝转移患者的预后分析及其生存列线图
- Author:
Bo LI
1
;
Haiyu WANG
2
;
Fengxia HE
3
;
Yongchen ZHANG
1
;
Jinhong YU
1
Author Information
1. Department of Laboratory Medicine, the Second Hospital of Nanjing, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China
2. Department of Oncology, the Second Hospital of Nanjing, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China
3. Department of Pathology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Liver metastases;
Prognostic analysis;
Nomogram
- From:
China Modern Doctor
2024;62(12):9-13,18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features and prognostic factors of gastric cancer patients liver metastasis.Methods Data from 7055 patients with gastric cancer were retrieved from Surveillance,Epidemiology and End Results(SEER)database between 2010 and 2015.The patients were divided into the liver metastases group(901 cases)and the non-liver metastases group(6154 cases)according to whether liver metastasis occurred.Univariate and multivariate Cox regression were used to analyze the prognostic risk factors,and the Kaplan-Meier method was used for survival analysis.Results There was a significant difference in age,gender,race,T stage,N stage,primary surgery,radiotherapy and tumor size between the two groups(P<0.05),and the median survival time of patients in the liver metastases group was 6 months,non-liver metastases group was 25 months.Cox regression analysis showed that age(P=0.009),tumor grade(P<0.001),surgery(P<0.001)and chemotherapy(P<0.001)were the main factors affecting the prognosis of gastric cancer with liver metastases.Conclusion Age,tumor grade,surgery and chemotherapy were the prognostic risk factors for gastric cancer with liver metastases.A nomogram based on age,tumor grade,surgery and chemotherapy has a good survival prediction significance for gastric cancer with liver metastases.
