Application of rhG-CSF in the treatment of chemotherapy-induced oral mucositis in children
10.3969/j.issn.1673-9701.2024.11.019
- VernacularTitle:rhG-CSF在治疗儿童化疗性口腔黏膜炎中的应用研究
- Author:
Yun HU
1
,
2
;
Dan NIE
1
,
2
;
Lei XIONG
1
,
2
Author Information
1. General Surgery Department of Jiangxi Children&rsquo
2. s Hospital, Nanchang 330038, Jiangxi, China
- Publication Type:Journal Article
- Keywords:
Chemotherapy-induced oral mucositis;
Recombinant human granulocyte macrophage colony stimulating factor;
Oral mucositis graduation;
Satisfaction
- From:
China Modern Doctor
2024;62(11):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application effect of recombinant human granulocyte colony stimulating factor(rhG-CSF)in the treatment of chemotherapy-induced oral mucositis in children.Methods Totally 60 children with chemotherapy-induced oral mucositis who underwent chemotherapy in the tumor surgery of our hospital from January 2020 to June 2022 were randomly divided into two groups,30 cases each.The control group was given physiological saline oral care,and the experimental group was given rhG-CSF oral care.Compare the intervention effect,oral mucositis grading,quality of life[short form of health survey(SF-36)]and nursing satisfaction of parents of the two groups.Results The total effective rate of the experimental group was higher than that of the control group(P<0.05).After 5 days of intervention,the score of oral mucositis in the experimental group was better than that in the control group(P<0.05).After 5 days of intervention,the SF-36 score of children in the two groups was higher than that before intervention,and that in the experimental group was higher than that in the control group(P<0.05).The parents'satisfaction in the experimental group was higher than that in the control group(P<0.05).Conclusion rhG-CSF oral care can effectively improve the intervention effect of chemotherapy-induced oral mucositis in children,reduce the grade of oral mucositis,improve the quality of life of children,and improve the nursing satisfaction of parents of children.
