Correlation between nociceptin/orphanin FQ(N/OFQ)and perioperative myocardial injury in elderly patients with coronary heart disease
10.3969/j.issn.1673-9701.2024.11.002
- VernacularTitle:孤啡肽与老年冠心病患者围术期心肌损伤的相关性研究
- Author:
Danyan ZHU
1
;
Chang XIONG
1
;
Wenyong PENG
1
;
Duojia XU
1
;
Zhijian LAN
1
Author Information
1. Department of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinghua 321000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Nociceptin/orphanin FQ(N/OFQ);
Elderly;
Coronary heart disease;
Perioperative myocardial injury;
Non-cardiac surgery
- From:
China Modern Doctor
2024;62(11):7-10,14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between perioperative myocardial injury(PMI)and serum N/OFQ levels in elderly patients with coronary heart disease.Methods Totally 120 elderly patients who underwent hip fracture surgery under general anesthesia from January 2022 to May 2023 were included,including 60 patients with coronary heart disease(CHD group)and 60 patients without coronary heart disease(control group).The venous blood of patients was collected 10 minutes before anesthesia induction(T0),12 hours after surgery(T1)and 24 hours after surgery(T2)to detect the content of N/OFQ and high-sensitivity myocardial troponin I(hs-cTnI)in serum.Record perioperative adverse cardiovascular events(PACE)and the use of vasoactive drugs during surgery.Results Compared with the control group,the N/OFQ and hs cTnI levels at T0 and T1 in the CHD group were significantly increased(P<0.05).There was a positive correlation between N/OFQ and hs-cTnI levels at T1 and T2 in CHD and control group(P<0.05).The use of PACE and intraoperative vasoactive drugs in the CHD group was higher than that in the control group(P<0.05).Conclusion There is a correlation between the increased N/OFQ content and PMI in elderly patients with coronary heart disease after surgery,which may become an early predictive indicator of PMI.
