Effect of Jiawei Jianshen prescription on patients with spleen-kidney deficiency of idiopathic membranous nephropathy and its influence on PLA2R
10.3969/j.issn.1673-9701.2024.10.013
- VernacularTitle:加味健肾方治疗特发性膜性肾病脾肾两虚证患者的疗效及对PLA2R的影响
- Author:
Chaoye LIU
1
;
Ronggui HUANG
1
;
Weiying ZHANG
1
;
Yifeng XIE
1
;
Zhu CHEN
1
Author Information
1. Department of Nephrology, Liuzhou Traditional Chinese Medical Hospital (Liujcouh Si Ywcuengh Yihyen), Liuzhou 545001, Guangxi, China
- Publication Type:Journal Article
- Keywords:
Idiopathic membranous nephropathy;
Spleen-kidney deficiency pattern;
Phospholipase A2 receptor
- From:
China Modern Doctor
2024;62(10):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Jiawei Jianshen prescription on idiopathic membranous nephropathy(IMN)with spleen-kidney deficiency and its influence on phospholipase A2 receptor(PLA2R)titer.Methods A total of 60 patients with IMN who were hospitalized or outpatients in Liuzhou Traditional Chinese Medical Hospital from January 2021 to July 2022 were selected and divided into control group and treatment group by simple random sampling method,with 30 cases in each group.The control group was given basic treatment alone,and the treatment group was given Jiawei Jianshen prescription + basic treatment.Blood urea nitrogen(BUN),serum creatinine(SCr),serum albumin(ALB),24h urinary protein quantitative and PLA2R titer were compared between two groups before and after treatment.The therapeutic effect of two groups was evaluated.Results The total effective rate of treatment group was significantly higher than that of control group(χ2=60.000,P<0.001).After treatment,the scores of edema,abdominal distension,fatigue,soreness and weakness of waist and knees in treatment group were significantly lower than those in control group(P<0.05).24h urinary protein and PLA2R titer in treatment group were significantly lower than those in control group,and ALB was significantly higher than that in control group(P<0.05).Conclusion Jiawei Jianshen prescription can significantly improve the clinical symptoms of IMN patients with spleen-kidney deficiency,increase serum ALB level,reduce 24h urinary protein quantity and PLA2R titer.
