Effects of the ultrafast pulse wave velocity for assessing carotid artery elasticity in patients with diabetes mellitus type 2 by SGLT-2 inhibitors
10.3969/j.issn.1673-9701.2024.09.020
- VernacularTitle:极速脉搏波技术评估SGLT-2抑制剂对2型糖尿病患者颈动脉弹性的影响
- Author:
Zhiwei WANG
1
;
Yanhong FENG
1
Author Information
1. Department of Ultrasound, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, Liaoning, China
- Publication Type:Journal Article
- Keywords:
Sodium-dependent glucose transporters 2;
Diabetes mellitus type 2;
Ultrafast pulse wave velocity;
Carotid artery elasticity
- From:
China Modern Doctor
2024;62(9):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of sodium-dependent glucose transporters 2(SGLT-2)inhibitors on carotid artery elasticity in patients with diabetes mellitus type 2 by applying the ultrafast pulse wave velocity(UFPWV).Methods A total of 82 patients with diabetes mellitus type 2 admitted to the First Affiliated Hospital of Jinzhou Medical University from January to June 2022 were selected and randomly divided into control group(n=41)and observation group(n=41),and both groups were treated with conventional hypoglycemic therapy,and patients in observation group were combined with the treatment of SGLT-2 inhibitor on the basis of control group,and the patients of both groups were treated for 1 year.Systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),carotid intima-media thickness(CIMT),and UFPWV technique was used to measure the common carotid artery pulse wave velocity-beginning of systole(PWV-BS)and pulse wave velocity-end of systole(PWV-ES).Results ①The comparison between SBP,DBP,BMI,FPG,2h PG,HbA1c,CIMT,PWV-BS,PWV-ES indexes of the two groups of patients before treatment,the difference was not significant(P>0.05);② After receiving treatment,SBP,DBP,BMI,FPG,2hPG,HbA1c,CIMT,PWV-BS,PWV-ES of patients in observation group were lower than those of control group before treatment,and the differences were statistically significant(P<0.05);③ FPG,2hPG,HbA1c,SBP,DBP,BMI,CIMT,PWV-BS,PWV-ES indexes of observation group were lower than those of control group after treatment,and the difference was statistically significant(P<0.05).Conclusion UFPWV can effectively assess the value of SGLT-2 inhibitors in improving carotid artery elasticity in patients with diabetes mellitus type 2 with high accuracy and simplicity.
