The correlation study of serum vaspin with atrial fibrosis biochemical markers in patients with atrial fibrillation
10.3969/j.issn.1673-9701.2024.09.009
- VernacularTitle:心房颤动患者血清vaspin与心房纤维化血清生化标志物的相关性研究
- Author:
Meiyu YAN
1
,
2
;
Shushu YU
1
,
2
;
Huizhu LIU
1
,
2
;
Ke TANG
1
,
2
;
Xiaopeng XU
1
,
2
;
Yiguan XU
1
,
2
;
Yun XIE
1
,
2
Author Information
1. Department of Cardiology, Shanghai Putuo District People&rsquo
2. s Hospital, Shanghai 200060, China
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Vaspin;
Atrial fibrillation;
Serum biochemical markers;
Correlation
- From:
China Modern Doctor
2024;62(9):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation of serum visceraladiposetissue-derived serineproteinase inhibitor(vaspin)and atrial fibrosis biochemical markers in atrial fibrillation(AF)patients.Methods The subjects were selected from inpatients in Shanghai Putuo District People's Hospital during January 2021 to October 2022.Enzyme linked immunosorbent assay(ELISA)was used to determine the levels of serum vaspin,C-terminal propeptide of prollagen type Ⅰ(PⅠCP),matrix metalloproteinase-1(MMP-1),N-terminal type Ⅲ collagen peptide(PⅢNP),tissue matrix metalloproteinase inhibitory factor-1(TIMP-1)of paroxysmal atrial fibrillation(PAF)group,persistent atrial fibrillation(PeAF)group,and control group.The correlation between serum vaspin and the above serum biochemical markers was analyzed.Results ①Levels of serum vaspin(9.51±1.47)ng/ml,PⅠCP(704.83±120.45)ng/ml,MMP-1(5.92±0.73)ng/ml,PⅢNP(63.34±12.24)ng/ml,and TIMP-1(7.56±0.90)ng/ml in PeAF group were significantly higher than those of PAF group and control group(P<0.05);②vaspin was significantly and positively correlated with PⅠCP,MMP-1,PⅢNP,TIMP-1 in PAF group and PeAF group.Conclusion Serum vaspin level of AF patients were significantly high and positively correlated with atrial fibrosis biochemical markers,which indicated that serum vaspin level might be closly related to atrial fibrosis in AF patients.It may be a potential marker to identify the degree of fibrosis in atrial fibrillation.
