Predictors and prognostic analysis of pathological complete response of axillary metastatic lymph nodes after neoadjuvant chemotherapy in breast cancer
10.3969/j.issn.1673-9701.2024.05.007
- VernacularTitle:乳腺癌新辅助化疗后腋窝转移淋巴结病理完全缓解的预测因素及预后分析
- Author:
Qin XU
1
;
Jun YUAN
2
;
Ping QIAN
1
;
Linna YUAN
3
;
Zhenyi MA
1
;
Ziran ZHANG
4
Author Information
1. Department of Pathology, Jiaxing Hospital of Traditional Chinese Medicine affiliated to Zhejiang Chinese Medicine University, Jiaxing 314000, Zhejiang, China
2. Department of Pathology, Jiaxing Maternity and Child Health Care Hospital, Jiaxing 314000, Zhejiang, China
3. Department of Pathology, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang, China
4. Department of Breast Diseases, Jiaxing Maternity and Child Health Care Hospital, Jiaxing 314000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Neoadjuvant chemotherapy;
Axillary lymph node;
Pathological complete response
- From:
China Modern Doctor
2024;62(5):30-34,39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological factors associated with pathological complete response(pCR)of axillary metastatic lymph nodes in breast cancer patients after neoadjuvant chemotherapy(NAC),and to analyze the postoperative survival.Methods A total of 116 patients with breast cancer with axillary lymph node metastasis were collected from Jiaxing Hospital of TCM,Jiaxing Maternity and Child Health Care Hospital and The First Hospital of Jiaxing.Univariate analysis was used to analyze the relationship between clinicopathological factors and the pCR of axillary lymph node metastasis in breast cancer after NAC.Binary Logistic regression was used to analyze the independent predictors of the pCR of axillary lymph node metastasis in breast cancer after NAC.Kaplan-Meier survival curve was used to analyze the disease-free survival rate and overall survival rate of patients with and non-pCR of axillary metastatic lymph nodes.Results Among 116 patients,52 cases of axillary metastatic lymph nodes achieved pCR after NAC,accounting for 44.83%.Univariate analysis showed that age,vascular invasion,pCR of primary breast tumor,the difference of Ki67 before and after NAC,NAC regimen,and the efficacy of NAC were statistically significant between breast cancer patients with pCR and those non-pCR(P<0.05).Binary Logistic regression analysis showed that age,vascular invasion and pCR of primary breast tumor were independent predictors of pCR of axillary metastatic lymph nodes(P<0.05).The 5-year disease-free survival rate(80.40%vs.54.60%)and overall survival rate(90.4%vs.70.10%)of patients with pCR and non-pCR of axillary metastatic lymph nodes were compared.Conclusion Some breast cancer patients with axillary lymph node metastasis can reach pCR in lymph nodes after NAC.Analyzing the correlation between clinical pathological factors and pCR of axillary metastatic lymph nodes after NAC,it was found that pCR of axillary metastatic lymph nodes after NAC is related to age≤50 years old,no vascular infiltration,and primary breast tumor pCR.At the same time,it was found that patients with axillary metastatic lymph node pCR had a better prognosis than those with non-pCR.
