Diagnostic value of hs-CRP and PCT combined with IL-6 in children with severe hand-foot-mouth disease
10.3969/j.issn.1673-9701.2024.05.004
- VernacularTitle:超敏C反应蛋白、降钙素原联合白细胞介素-6对手足口重症患儿的诊断价值研究
- Author:
Lijun LUO
1
;
Chenggao XU
2
;
Fei SUN
1
;
Xiaohui GAO
1
;
Shunfeng MAO
1
;
Xiaoping LU
1
;
Junjie FENG
1
Author Information
1. Department of Pediatrics, the First Hospital of Jiaxing, Jiaxing 314000, Zhejiang, China
2. Department of Endocrinology, the First Hospital of Jiaxing, Jiaxing 314000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Hand,foot and mouth disease;
Hypersensitive C-reactive protein;
Procalcitonin;
Interleukin-6;
Diagnostic value
- From:
China Modern Doctor
2024;62(5):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value and clinical significance of hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT)combined with interleukin-6(IL-6)in children with severe hand-foot-mouth disease.Methods A total of 62 children hospitalized in our hospital from January 2022 to December 2022 were collected as research objects.According to the severity of infection,they were divided into observation group(severe infection group)with 29 cases and control group(mild infection group)with 33 cases.The differences of general data,total leukocyte count,neutrophil count,lymphocyte count,platelet count,hs-CRP,PCT,IL-6 and creatine kinase isoenzyme(CK-MB)between the two groups and their clinical applications were analyzed and compared.Results The total white blood cell count,neutrophil count,lymphocyte count,hs-CRP,PCT and IL-6 in the observation group were higher than those in the control group,and the difference has statistically significant.Receiver operator characteristic(ROC)curve analysis of hs-CRP predicted the sensitivity and specificity of severe infection of hand-foot-mouth disease were 79.3%and 93.9%(95%CI:0.852-10.985,P<0.05);The sensitivity and specificity of PCT were 93.1%and 84.8%(95%CI:0.907-1,P<0.05);The sensitivity and specificity of IL-6 were 96.6%and 87.9%(95%CI:0.945-1,P<0.05).Conclusions In hand-foot-mouth classification,PCT and IL-6 are highly sensitive.Although hs-CRP is less sensitive than the former,its specificity is higher than the former.Therefore,the combination of hs-CRP,PCT and IL-6 has higher value for hand-foot-mouth classification.
