Effects of growth hormone co-treatment with progesterone-primed ovarian stimulation protocol on IVF outcomes in women with low prognosis
10.3969/j.issn.1673-9701.2024.05.002
- VernacularTitle:生长激素协同高孕激素促排卵方案对低预后女性体外受精结局的影响
- Author:
Jianeng ZHANG
1
,
2
;
Huanhuan ZHANG
1
,
2
;
Chong WANG
1
,
2
Author Information
1. Reproductive Endocrinology Center, Hangzhou Women&rsquo
2. s Hospital, Hangzhou 310000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Growth hormone;
In vitro fertilization;
Progesterone-primed ovarian stimulation;
Low prognosis;
Propensity score matching
- From:
China Modern Doctor
2024;62(5):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of growth hormone(GH)with progesterone-primed ovarian stimulation(PPOS)protocol on in vitro fertilization(IVF)outcomes among women with low prognosis.Methods This is a retrospective cohort study using propensity score matching(PSM)analysis.Women commencing their IVF between January2017 to December2021,with and without GH co-treatment,were reviewed.Results After PSM,76 pairs of women with low prognosis were included into analysis.Paired testing showed there is a statistical increase in transferable embryo(P<0.001)in the GH co-treatment group comparing with control group.No significant difference showed in retrieved oocyte number and metaphaseⅡ(MⅡ)oocyte rate,two-pronuclear(2PN)zygote rate on day1,high-quality embryo rate,or clinical pregnancy rate,neither in gonadotropin(Gn)requirement,duration or peak estradiol.Subgroup analysis results showed transferrable embryo rate on day3 rising among decreased ovarian reserve women(P=0.010).For women aged below 40,MⅡoocyte rate(P=0.010)and transferrable embryo rate on day3(P<0.001)increased in GH co-treatment group.Conclusions GH is suggested a beneficial impact on oocyte quality and transferrable embryos with PPOS protocol in IVF.Its adjuvant administration can be proposed as an optional therapeutic strategy in women with low prognosis.
