Effect of Gexia Zhuyu decoction combined with diosmin on coagulation mechanism after great saphenous varicose vein surgery
10.3969/j.issn.1673-9701.2024.04.016
- VernacularTitle:膈下逐瘀汤联合地奥司明对大隐静脉曲张术后凝血机制的影响
- Author:
Feihu ZHI
1
;
Xiongbi ZHAO
1
;
Jianyu ZHANG
1
;
Shuyang ZHANG
1
;
Yuanwei REN
1
Author Information
1. Department of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing 321000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Great saphenous varicose vein;
Gexia Zhuyu decoction;
Diosmin;
Coagulation mechanism;
Inflammatory factor
- From:
China Modern Doctor
2024;62(4):64-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Gexia Zhuyu decoction combined with diosmin on coagulation mechanism in patients with great saphenous varicose vein surgery.Methods A total of 60 patients who received great saphenous varicose vein surgery in Shaoxing Hospital of Traditional Chinese Medicine from January 2019 to April 2022 were selected and divided into control group and observation group according to random number table method,with 30 patients in each group.Control group was treated with diosmin,and observation group was treated with diosmin + Gexia Zhuyu decoction.Coagulation indexes,vascular endothelial function and inflammatory factor levels were compared between two groups.Results After treatment,Krüppel-like factor 2,activated partial thromboplastin time,thrombin time,prothrombin time,nitric oxide,and interleukin(IL)-10 in observation group were significantly higher than those in control group,while plasminogen activator inhibitor type 1,von Willebrand factor,endothelin 1,hypersensitive C-reactive protein,IL-2 and IL-6 were significantly lower than those in control group(P<0.05).Conclusion Gexia Zhuyu decoction combined with diosmin can improve the hypercoagulable state and vascular endothelial function in patients with great saphenous varicose vein surgery,and reduce the level of inflammatory factors in the body,which is worth popularizing.
