Effects of Sushen Jiubao decoction on Th1/Th2 factors in patients with acute exacerbation of bronchial asthma
10.3969/j.issn.1673-9701.2024.01.017
- VernacularTitle:苏沈九宝汤对支气管哮喘急性发作患者Th1/Th2因子的影响
- Author:
Yiping ZHANG
1
;
Xiaofang LIAO
1
;
Jiancheng ZHUGE
1
;
Bingheng LOU
2
Author Information
1. Intensive Care Unit, Sishengbianji Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Quzhou 324002, Zhejiang, China
2. Department of Emergency, Quzhou Emergency Command Center, Quzhou 324000, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Sushen Jiubao decoction;
Pulmonary function;
Th1/Th2;
Acute exacerbation
- From:
China Modern Doctor
2024;62(1):70-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of Sushen Jiubao decoction in the treatment of acute exacerbation of bronchial asthma and its effect on Th1/Th2 factors.Methods Ninety-eight patients with acute exacerbation of bronchial asthma treated in Sishengbianji Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from February 2022 to May 2023 were selected and divided into treatment group and control group according to random number table method,with 49 cases in each group.The control group was given conventional treatment such as oxygen inhalation and atomization,and the treatment group was additionally treated with Sushen Jiubao decoctionon based on the treatment of control group.The clinical efficacy,TCM syndrome score,pulmonary function indicators[forced expiratory volume in first second(FEV1),peak expiratory flow(PEF)],and laboratory indicators[interleukin(IL)-4,IL-13,interferon-γ(IFN-γ),immunoglobulin E(IgE)].Results The total effective rate of treatment group was significantly higher than that of control group(χ2=9.287,P=0.010).After treatment,the TCM syndrome scores,serum IL-4,IL-13 and IgE levels of two groups were significantly lower than before treatment,and FEV1,PEF and IFN-γ were significantly higher than before treatment(P<0.05).The TCM syndrome score,serum IL-4,IL-13 and IgE levels in treatment group were significantly lower than those in control group,and FEV1,PEF and IFN-γ were significantly higher than those in control group(P<0.05).Conclusion Sushen Jiubao decoction can significantly improve clinical efficacy,reduce the level of inflammatory factors,and improve pulmonary function in the treatment of acute exacerbation of bronchial asthma.
