Mechanism of Buyang Huanwu decoction in the treatment of spinal cord injury based on network pharmacology
10.3969/j.issn.1673-9701.2024.01.016
- VernacularTitle:基于网络药理学研究补阳还五汤治疗脊髓损伤的作用机制
- Author:
Musen ZHONG
1
;
Zhongcheng AN
2
;
Guangya FAN
1
;
Jiqian BAO
1
;
Wenshuo SU
1
;
Liqiang DONG
2
Author Information
1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
2. Department of Orthopedics, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Buyang Huanwu decoction;
Spinal cord injury;
Network pharmacology;
Mechanism of action;
Molecular docking
- From:
China Modern Doctor
2024;62(1):63-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the mechanism of Buyang Huanwu decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking.Methods The active ingredients and targets of Buyang Huanwu decoction were screened out by TCMSP,SymMap,PubChem and Swiss Target Prediction databases.Spinal cord injury targets were retrieved from OMIM,GeneCards,TTD,and DrugBank databases.Through venny software,the intersection target of Buyang Huanwu decoction and spinal cord injury was obtained.The active ingredient-target network for the treatment of spinal cord injury was constructed with Cytoscape software.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of common targets were carried out by DAVID,and the binding ability of drugs and targets was analyzed by molecular docking technology.Results A total of 106 active ingredients and 225 targets of Buyang Huanwu decoction,1315 targets of spinal cord injury and 112 targets of drug-disease intersection were obtained.The active ingredients of Buyang Huanwu decoction were quercetin,kaempferol,ellagic acid,luteolin and hederagenin in the treatment of spinal cord injury.Conclusion Buyang Huanwu decoction can achieve the purpose of treating spinal cord injury through various signal pathways.
