Clinical significance analysis of peripheral blood inflammation indexes in schizophrenia
10.3969/j.issn.1673-9701.2024.01.013
- VernacularTitle:外周血炎症指标在精神分裂症中的临床意义分析
- Author:
Shiying LI
1
;
Yanting JIANG
1
;
Xi LI
1
;
Jian WANG
1
Author Information
1. Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Neutrophil to albumin ratio;
Monocyte to lymphocyte ratio;
Systemic immune-inflammation index
- From:
China Modern Doctor
2024;62(1):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of neutrophil to albumin ratio(NAR),neutrophil to lymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR)and systemic immune-inflammation index(SII)in schizophrenia.Methods A total of 215 patients with schizophrenia admitted to Nanning Social Welfare Hospital from January 2019 to June 2021 were included in schizophrenia group,and 113 healthy people who underwent physical examination in hospital during the same period were included in control group.NAR,NLR,MLR,PLR,SII of two groups were compared,and the correlation between them and the clinical symptom score of schizophrenia and changes after taking antipsychotic drugs were analyzed.Results The levels of NAR,NLR,PLR,MLR and SII in schizophrenia group were significantly higher than those in control group(P<0.05).Spearman correlation analysis showed that NAR,NLR,SII and scale for the assessment of positive symptom scores were negatively correlated(P<0.05).After treatment with antipsychotic drugs,all inflammatory indexes were decreased in schizophrenia group,but NAR and MLR were still significantly higher than those in control group(P<0.05).Conclusion There is an active state of immune inflammation in schizophrenia,and the levels of NAR and MLR do not decrease significantly after treatment with antipsychotic drugs,which may be related to the persistence of schizophrenia symptoms.
