Research on risk factors of primary hepatic carcinoma in patients with hepatitis B virus-related liver cirrhosis
10.3969/j.issn.1673-9701.2023.36.009
- VernacularTitle:乙型病毒性肝炎肝硬化患者发生原发性肝癌的危险因素分析
- Author:
Ling LEI
1
;
Nian FANG
;
Peng LIU
;
Dan WU
;
Lihong GAN
;
Li ZHENG
Author Information
1. 南昌市第一医院消化内科,江西南昌 330008
- Keywords:
Primary hepatic carcinoma;
Hepatic cirrhosis;
Risk factors;
Preventive treatment
- From:
China Modern Doctor
2023;61(36):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the risk factors for development of primary hepatic carcinoma(PHC)in patients with hepatitis B virus-related liver cirrhosis.Methods The cases of hepatitis B virus-related liver cirrhosis combined with PHC and hepatitis B virus-related liver cirrhosis alone were retrospectively analyzed in the Second Affiliated Hospital of Nanchang University.A total of 151 patients with hepatitis B virus-related liver cirrhosis combined with PHC were included in observation group and 136 patients with hepatitis B virus-related liver cirrhosis alone were included in control group.We have down the analysis of risk factors by χ2 test,t test and Logistic regression model.Results The clinical data of the two groups of patients showed statistically significant differences in six indicators,including gender,hepatitis B virus e antibodies(Anti-HBe),liver function grading(Child-Pugh),alpha-fetoprotein(AFP),blood glucose,and blood type,through univariate analysis(P<0.05).The results of multivariate unconditional Logistic regression analysis showed that AFP(OR=5.046,2.716,and 9.373,P<0.01)and Anti-HBe positive(OR=2.305,1.075,and 4.945,P<0.01)were risk factors for primary liver cancer.Conclusion Male shows a more possibility of occurrence of PHC than female.The positive Anti-HBe is the independent risk factors for PHC.The probability of PHC in Child-Pugh stage A is higher than that in Child-Pugh stage B and C.
