Study on immune related indexes in children with bronchial asthma during acute attack
10.3969/j.issn.1673-9701.2023.36.006
- VernacularTitle:儿童支气管哮喘急性发作期免疫相关指标研究
- Author:
Xianli QI
1
;
Liying MAO
Author Information
1. 诸暨市妇幼保健院儿科,浙江诸暨 311800
- Keywords:
Bronchial asthma;
Children;
Immunoglobulin;
Complement;
T lymphocyte subsets
- From:
China Modern Doctor
2023;61(36):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the levels of immunoglobulin(Ig)G,IgM,factor B,complement C3 and C4,T lymphocyte subsets in children with bronchial asthma during acute attacks and their correlation with the severity of the disease.Methods The clinical data of 133 children with bronchial asthma admitted to the Department of Pediatrics,Zhuji Maternal and Child Health Hospital from January 2020 to July 2022 were analyzed.According to whether the children were in acute exacerbation stage,they were divided into acute stage group(85 cases)and stable stage group(48 cases);The data about the levels of IgG,IgM,factor B,complement C3 and C4,T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)on admission were collected from the two groups of children;The acute phase and stable phase were analyzed.The changes of the above indicators,compared the changes of the above indicators in children with different acute attack;Spearman linear equation was used to analyze the correlation between Ig,complement,and T lymphocyte subsets levels and the severity of the disease.Results The level of IgG,factor B,IgM,C3 and C4 were lower than those in stable stage group,with statistical significance(P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in acute stage group were lower than those in stable stage group,and the difference was statistically significant(P<0.05).With the improvement of the severity grade of acute asthma attack,the levels of factor B,C3,C4,CD3+,CD4+ and CD4+/CD8+ decreased gradually,and the differences among different grades were statistically significant(P<0.05).There was no significant difference in IgG level among different severity grades(P>0.05).Spearman linear correlation analysis showed that the levels of factor B,IgM,C3,C4,CD3+,CD4+ and CD4+/CD8+ were negatively correlated with the severity of the disease(P<0.05).Conclusion There is obvious immune dysfunction in children with acute attack of bronchial asthma.Monitoring the levels of Ig,complement and T lymphocyte subsets is helpful to evaluate the severity of the disease.
