Observation of auxiliary efficacy of minocycline ointment on local inflammatory response in chronic periodontitis
10.3969/j.issn.1673-9701.2023.35.017
- VernacularTitle:米诺环素软膏对慢性牙周炎局部炎症反应的辅助疗效观察
- Author:
Yangyang YE
1
Author Information
1. 温州市中心医院,浙江温州 325000
- Keywords:
Minocycline ointment;
Chronic periodontitis;
Inflammatory response;
Clinical efficacy
- From:
China Modern Doctor
2023;61(35):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of minocycline ointment in chronic periodontitis and its auxiliary efficacy on local inflammatory response.Methods From February to September 2022,88 patients with chronic periodontitis treated were randomly divided into control group(routine treatment)and study group(treated with minocycline ointment),44 cases in each group.The clinical therapeutic effects,inflammatory factors in gingival crevicular fluid,periodontal improvement and collagen indexes of the two groups were compared.Results At 2 weeks of treatment,the total clinical effective rates of the two groups were 81.82%and 63.64%respectively.The study group was slightly higher than the control group,but the difference was not statistically significant(P>0.05).At 4 weeks of treatment,the total effective rate in the study group(95.45%)was higher than that in the control group(77.27%),the difference was statistically significant(P<0.05).At 2 and 4 weeks of treatment,the levels of hypersensitive-C-reactive protein and interleukin-10 inflammatory factors in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).At 2 and 4 weeks of treatment,the levels of plaque index,gingival index and periodontal pocket depth in the study group were better than those in the control group,and the differences were statistically significant(P<0.05).after one course of treatment and two courses of treatment,the collagen index of gingival crevicular fluid in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Minocycline ointment can improve the inflammatory reaction process and microecological balance of local periodontal tissue in patients with chronic periodontitis.It has important clinical significance for promoting the recovery of periodontal tissue and is one of the ideal ways for clinical treatment of chronic periodontitis.
