Relationship between cognitive and psychiatric symptoms and serum folate,homocysteine,vitamin B12 in patients with Alzheimer's disease
10.3969/j.issn.1673-9701.2023.34.014
- VernacularTitle:AD患者认知和精神症状与叶酸、同型半胱氨酸、维生素B12水平的关系
- Author:
Limin HE
1
;
Dake WANG
Author Information
1. 杭州市第七人民医院检验科,浙江杭州 310013
- Keywords:
Alzheimer's disease;
Cognitive function;
Psychiatric symptom;
Folate;
Homocysteine;
Vitamin B12
- From:
China Modern Doctor
2023;61(34):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between cognitive and psychiatric symptoms and serum folate,homocysteine(Hcy)and vitamin B12 in patients with Alzheimer's disease(AD).Methods Fifty-eight patients with AD who were treated in Hangzhou Seventh People's Hospital from March 2019 to April 2022 were retrospectively selected.According to the score of neuropsychiatric inventory questionnaire(NPI-Q),they were divided into observation group A(NPI-Q<14 points,36 cases)and observation group B(NPI-Q≥14 points,22 cases).Fifty-eight elderly persons who underwent physical examination during the same period were included in control group.The general data,serum folate,Hcy,vitamin B12 levels,mini-mental state examination(MMSE)score,NPI-Q score,clinical dementia rating(CDR)score were compared among the three groups.Results There was statistical significance in age comparison among the three groups(P<0.05),that is control group0.05).There were significant differences in MMSE,NPI-Q,CDR scores and serum folate,Hcy and vitamin B12 levels among the three groups(P<0.05).After controlling for variables,MMSE score was positively correlated with folate and negatively correlated with Hcy;NPI-Q score was negatively correlated with folate and vitamin B12,and positively correlated with Hcy;CDR score was negatively correlated with folate and vitamin B12,and positively correlated with Hcy(P<0.05).Serum Hcy levels in AD patients with emotional symptoms or psychiatric symptoms or impaired frontal lobe function were significantly higher than those in asymptomatic AD patients(P<0.05).Conclusion Detection of serum folate,Hcy,vitamin B12 levels is beneficial to the diagnosis of AD patients.
