Application of injection autologous tissue homogenate implantation in surgical treatment of secondary hyperparathyroidism
10.3969/j.issn.1673-9701.2023.34.008
- VernacularTitle:注射式自体组织匀浆移植术在继发性甲状旁腺功能亢进症手术治疗中的应用研究
- Author:
Sheng XIAO
1
;
Fei DENG
;
Tianwei XIE
;
Shuang YANG
;
Xun JIAN
Author Information
1. 成都市金牛区人民医院(四川省人民医院金牛医院)肾内科,四川成都 610007
- Keywords:
Parathyroidectomy;
Homogenate injection;
Implantation;
Hyperparathyroidism
- From:
China Modern Doctor
2023;61(34):31-33,80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of injectable autogenous tissue homogenate implantation in surgical treatment of secondary hyperparathyroidism(SHPT).Methods A total of 46 patients with SHPT who underwent long-term regular hemodialysis and failed medical treatment in Sichuan Mianyang 404 Hospital from June 2017 to June 2021 were selected.According to random number table method,the patients were divided into homogenate injection group and particle embedding group,with 23 cases in each group.Parathyroidectomy(PTX)plus autogenous forearm injection homogenate implantation was performed in homogenate injection group,and PTX plus autogenous forearm particle implantation was performed in particle embedding group.The changes in blood calcium,blood phosphorus,intact parathyroid hormone(iPTH),and alkaline phosphatase(ALP)of two groups before and after operation,as well as the improvements in vascular calcification,pruritus,bone pain,and sleep disorders after operation were compared.Results One year after surgery,the serum calcium level of two groups were significantly higher than before treatment,and the serum phosphorus,iPTH and ALP levels were significantly lower than before treatment(P<0.05).The serum calcium level in homogenate injection group was significantly higher than that in particle embedding group,and the serum phosphorus,iPTH and ALP levels were significantly lower than those in particle embedding group(P<0.05).The improvement of blood vessel calcification,pruritus,bone pain and sleep disorder in homogenate injection group were better than those in particle embedding group(P<0.05).Conclusion Injectable autologous tissue homogenate implantation for refractory SHPT patients is safe and effective,with high success rate,less trauma,and can improve patient symptoms and quality of life.
