Risk factors for pulmonary infection in patients with lung cancer after chemotherapy:A Meta-analysis
10.3969/j.issn.1673-9701.2023.34.004
- VernacularTitle:肺癌化疗患者发生肺部感染危险因素的Meta分析
- Author:
Shuangyan XIE
1
;
Sijin LI
;
Zeyun LI
;
Amin MA
;
Yonglan YU
;
Du XIE
Author Information
1. 广州中医药大学第一附属医院放射治疗科 广东省中医临床研究院,广东广州 510405
- Keywords:
Lung cancer;
Chemotherapy;
Pulmonary infection;
Risk factor;
Meta analysis
- From:
China Modern Doctor
2023;61(34):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Methods CNKI,Wanfang Data,VIP,PubMed,Embase,and the Cochrane Library were searched from inception to October 2022 to collect case-control studies and cohort studies about risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Two researchers independently conducted literature screening,data extraction,and quality assessment.Rev Man 5.3 software was used for Meta-analysis.Results A total of 15 literatures were included,including 3960 patients with lung cancer after chemotherapy.Meta analysis results showed that age≥60 years,smoking history,drinking history,hypertension,diabetes mellitus,atelectasis,hypoproteinaemia,TNM staging of stage Ⅲ-Ⅳ,central lung cancer,small cell lung cancer,invasive operation,Karnofsky performance status score＜80 points before chemotherapy,combined chemotherapy drugs,duration of chemotherapeutic ?2 weeks,white blood cell count≤3.0×109/L after chemotherapy,albumin＜30g/L after chemotherapy,and hospital stay>20 days were risk factors for pulmonary infection in patients with lung cancer after chemotherapy(P＜0.05).Conclusion There were many risk factors for pulmonary infection in patients with lung cancer after chemotherapy.Prevention and control measures should be taken based on the related risk factors to reduce the incidence rate of pulmonary infection.
