Effect of cognitive behavioral therapy on mental status and cellular immune function in breast cancer patients with postoperative chemotherapy
- VernacularTitle:认知行为治疗对乳腺癌术后化疗患者心理状态及细胞免疫功能的影响
- Author:
Xiaomin ZENG
1
;
Weibin YANG
Author Information
1. 浙江省丽水市中心医院甲状腺乳腺外科
- Keywords:
Breast cancer;
Postoperative chemotherapy;
Cognitive behavioral therapy;
Psychological status;
Cellular immunity
- From:
China Modern Doctor
2018;56(15):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cognitive behavioral therapy on psychological status and cellular immune function in patients with postoperative chemotherapy of breast cancer. Methods 70 breast cancer patients with postoperative chemotherapy from January 2014 to August 2017 were randomly divided into intervention group and control group. Both groups underwent CMFchemotherapy. The control group received routine intervention during the chemotherapy, and the intervention group received cognitive behavioral therapy on the basis of the treatment of the control group. Both groups were intervened for 3 months. The changes of psychological status and cellular immune function before and after treatment between two groups were observed and compared. Results The SDSand SASscores of both groups decreased to different degrees after 3 months of intervention(P＜0. 05 or P＜0. 01), and SDSand SASscores in the intervention group were lower than those of control group(P＜0. 05). The levels of CD4+ and the ratio of CD4+/ CD8+ in the intervention group increased at different degrees, and the levels of CD8+ in the intervention group decreased to different degrees (P＜0. 05 or P＜0. 01), while those in the control group did not change significantly (P＞0. 05). After treatment, the level of CD4+ and the ratio of CD4+/CD8+ in intervention group was higher than that in control group, and the level of CD8+ in the intervention group was lower than that in control group (P＜0. 05 or P＜0. 01). Conclusion Cognitive behavioral therapy is effective for patients with postoperative chemotherapy of breast cancer, which not only can significantly improve their psychological status and relieve their depression and anxiety states, but also regulate the disturbance of Tlymphocyte subsets and enhance the cellular immune function.
