Research on the correlation between syndrome differentiation of traditional Chinese medicine(TCM) and the clinical stage, histological type and EGFRgene in patients with lung cancer
- VernacularTitle:肺癌患者中医辨证与临床分期、组织分型及EGFR相关性研究
- Author:
Xiaoyi XU
1
;
Jinjin ZHOU
;
Lei WANG
;
Yuan XU
;
Hongwen SHEN
Author Information
1. 浙江省衢州市中医医院肿瘤科
- Keywords:
Lung cancer;
Syndrome differentiation of TCM;
Clinical stage;
Histopathological type;
EGFRgene
- From:
China Modern Doctor
2018;56(15):81-83,87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between syndrome differentiation of traditional Chinese medicine (TCM) and the clinical stage of western medicine, histological type and EGFRgene in patients with lung cancer and to find out the regularity among them. Methods From February 2015 to September 2017, 101 patients with lung cancer were enrolled in this study. Statistical analysis of relationship between TCMsyndrome differentiation and clinical stage, histopathological type and EGFRgene expression was carried out. Results There was a significant difference (P＜0. 05) between TCMtypes and histopathological types of lung cancer(P＜0. 05), among which, there was a significant difference (P＜0. 05) between adenocarcinoma and small cell lung cancer and non-adenocarcinoma. There also had a significant difference(P＜0. 05) between TCMtypes and TNMstage of lung cancer. Intergroup analysis demonstrated that there was a significant difference (P＜0. 05) between stage Iand IV, and also stage Ⅱ and IV. There was a significant difference (P＜0. 05) between TCMtypes and positive expression of EGFR. From phlegm-heat syndrome, qi-stagnation syndrome, qiyin deficiency syndrome to cold-dampness syndrome, The positive expression of EGFRwas gradually ascending. There was significant difference between cold-dampness syndrome and phlegm-heat syndrome(P＜0. 05). Conclusion There is a certain correlation between syndrome differentiation of TCMand clinical stage, histopathological classification and EGFRgene expression in lung cancer, which can provide dialectical evidence for objective and standardized TCMsyndrome differentiation.
