Drug-Induced Anaphylaxis in a Single Korean Tertiary Hospital.
10.3904/kjm.2015.88.3.281
- Author:
Il Joo MOON
1
;
Hye Jung PARK
;
Sung Ryeol KIM
;
Beom Seok KOH
;
Dong Woo LEEM
;
Kyung Hee PARK
;
Jae Hyun LEE
;
Jung Won PARK
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. jhleemd@yuhs.ac
- Publication Type:Original Article
- Keywords:
Anaphylaxis;
Epidemiology;
Epinephrine;
Adverse drug reaction
- MeSH:
Adrenal Cortex Hormones;
Anaphylaxis*;
Anti-Bacterial Agents;
Contrast Media;
Drug-Related Side Effects and Adverse Reactions;
Emergency Service, Hospital;
Epidemiology;
Epinephrine;
Histamine Antagonists;
Humans;
Korea;
Medical Records;
Neuromuscular Blockade;
Neuromuscular Blocking Agents;
Outpatients;
Ranitidine;
Retrospective Studies;
Tertiary Care Centers*;
Vitamins
- From:Korean Journal of Medicine
2015;88(3):281-287
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute. METHODS: This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013. RESULTS: Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%). CONCLUSIONS: In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA.
