Neuroprotective effect of granulocyte colony-stimulating factor and clinical research progress
- VernacularTitle:粒细胞集落刺激因子的神经保护作用及临床试验研究进展
- Author:
Wei LUO
1
;
Siyun SHU
;
Lin MA
;
Bin WANG
Author Information
1. 南方医科大学珠江医院儿科中心 广州市炎症与免疫性疾病重点实验室
- Keywords:
Granulocyte colony -stimulating factor;
Nerve injury disease;
Neonatal hypoxic -ischemic brain damage;
Neuroprotection;
Clinical trials
- From:
China Modern Doctor
2018;56(14):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Granulocyte colony -stimulating factor, as a growth factor that stimulates bone marrow hematopoiesis, is clinically used to treat neutropenia caused by various causes. However, more and more in vitro and in vivo research experiments and clinical trials have shown that granulocyte colony-stimulating factor exerts neuroprotective effects in nervous system injury diseases by activating multiple signal transduction pathways, including mobilizing peripheral stem cells to migrate to the nervous system, reducing nerves apoptosis, balancing inflammatory responses, and promoting neural stem cell regeneration and angiogenesis, but there is also some controversy. Currently, the use of granulocyte colony-stimulating factor therapy in stroke, amyotrophic lateral sclerosis and spinal cord injury has entered clinical trials, and its efficacy has also been confirmed in a neonatal animal model of hypoxic-ischemic brain damage. The neuro-protective effects of granulocyte colony-stimulating factor and the safety and efficacy of clinical trials are reviewed.
