Clinical observation of dexmetimidine in the replacement of propofol in patients with painless induced abortion
- VernacularTitle:右美托咪定替代丙泊酚用于无痛流产的临床观察
- Author:
Huashan ZHANG
1
;
Zhenguo PAN
;
Mingyi WANG
Author Information
1. 山东省聊城市第二人民医院麻醉科
- Keywords:
Dexmetimidine;
Propofol;
Induced abortion;
Sedation;
Respiratory depression
- From:
China Modern Doctor
2018;56(14):124-126,131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility and safety of dexmetimidine (Dex) in the replacement of propofol in patients with induced abortion. Methods 172 patients aged 16 years to 38 years who were through induced abortion at ASA I grade of primary pregnancy in the outpatient department of our hospital were selected. Patients were randomized into group D and group C with 86 patients in each. Patients in group D were treated with Dex 0. 8-1. 0 μg/kg at first and a compound of sulfentanyl 0. 1 μg/kg. Patients in group C were treated with propofol injection 2. 0-2. 5 mg/kg compounded with sulfentanyl 0. 01 μg/kg. Additional administration was performed when necessary to keep bispectral index(BIS) stable at the value of (55土10). The induction duration (time from the beginning of induction to the time when operation could be performed), heart rate(HR), pulse, blood oxygen saturation(Sp02), systolic blood pressure(SBP)and diastolic blood pressure (DBP), capacity of calculation at the time point and 5 minutes after BIS was back to 85 and more, and the times of intervention to complications in two groups were recorded. Results Sedation status of pregnant women in two groups met the requirements of operation. Induction duration and wake-up time in group D were statistically longer than those in group C. Capacity of calculation at the time point that BIS was back to 85 and more in group D was statistically higher than that in group C. There was no difference of capacity of calculation 5 minutes after BIS was back to 85 and more between group D and C. Conclusion Dex could replace the propofol to be applied in the anaesthesia of induced abortion. Though the respiratory depression effect of Dex was less, it needs to pay attention to the occurrence of low heart rate.
