Curative effect of rTMS stimulation in different brain regions combined with paroxetine on the treatment of obsessive-compulsive disorder
- VernacularTitle:rTMS刺激不同脑区联合帕罗西汀治疗强迫症的疗效研究
- Author:
Jimeng LIU
1
;
Zezhong FANG
;
Shugui GAO
;
Haihang YU
;
Dongsheng ZHOU
Author Information
1. 宁波市康宁医院情感科
- Keywords:
Repetitive transcranial magnetic stimulation;
Obsessive-compulsive disorder;
Paroxetine;
Yale-Brown obsessive compulsive scale
- From:
China Modern Doctor
2018;56(14):104-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rTMS stimulation in different brain regions combined with paroxetine on treating patients with obsessive -compulsive disorders. Methods Outpatients and inpatients with obsessive-compulsive disorder(OCD) treated at Kangning Hospital of Ningbo province from March 2015 to December 2016 were collected. Patients were randomly divided into control group(29 cases), treatment group 1(30 cases) and treatment group 2(30 cases). Patients in control group were treated with paroxetine only. Patients in treatment group 1 received rTMS stimulation of right prefrontal lobe combined with paroxetine systemic treatment. Patients in treatment group 2 received rTMS stimulation of bilateral supplementary motor area with paroxetine treatment. Obsessive -compulsive idea and behavior were assessed using Y-BOCS before treatment and 1, 2, 4, 6, 8 weeks after treatment. Adverse reaction was assessed after treatment with TESS. Results The Y-BOCS score of the control group decreased significantly at the 6th and the 8th week of treatment compared with before (P＜0. 05). The Y-BOCS score of the treatment group 1 and group 2 were significantly lower at 4, 6 and 8 weeks of treatment than that of the control group (P＜0. 05). The Y-BOCS scores of treatment group 1 and group 2 were significantly lower after 4 weeks of treatment than those before treatment (P＜0. 05). Conclusion rTMS stimulation of the right prefrontal lobe and bilateral supplementary motor area combined with paroxetine in the treatment of obsessive -compulsive disorder has consistent efficacy and take effect rapidly with minor adverse reactions.
