Correlation analysis between interferonγ -inducible protein -10 and expression of PPAR and FABP-4 in pregnant women with preeclampsia
- VernacularTitle:干扰素γ诱导蛋白10与子痫前期孕妇PPAR、FABP-4表达的相关性分析
- Author:
Caiping ZHANG
1
;
Suxian FU
;
Min ZHU
Author Information
1. 浙江省金华市人民医院产科
- Keywords:
Interferon γ-inducible protein 10;
Peroxisome proliferator activated receptor;
Fatty acid-binding protein 4;
Correlation
- From:
China Modern Doctor
2018;56(14):58-60,64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between interferon γ-inducible protein-10 and expression of peroxisome proliferator-activated receptor (PPAR) and fatty acid-binding protein-4 (FABP-4) in pregnant women with preeclampsia. Methods 62 PE pregnant women who were treated in our hospital from January 2016 to January 2017 were enrolled in this study. They were divided into mild PE group (34 cases) and severe PE group (28 cases) according to their severity of disease. In addition, 30 healthy pregnant women in our hospital were selected as the control group. The levels of IP-10 in the three groups were measured by enzyme-linked immunosorbent assay (ELISA), and the levels of PPAR and FABP-4 and the correlation between them were analyzed using western blot assay. Results The levels of IP-10 in mild and severe PE pregnant women were significantly higher than those in the control group, and the mild group was lower than the severe group(P＜0. 05). Compared with the control group, the level of PPAR in mild and severe PE pregnant women decreased significantly, and the severe group was lower than the mild group (P＜0. 05). Compared with the control group, FABP-4 levels in mild and severe PE groups were significantly elevated, and the mild groups was lower than the severe group(P＜0. 05). There was a negative correlation between the level of PPAR and IP-10 (r=-0. 529, P＜0. 05), and a positive correlation between FABP-4 and IP-10(r=0. 692, P＜0. 05). Conclusion There is a certain correlation between PPAR and FABP-4 and the level of IP-10 in pre-PE pregnant women. lt can be used to determine the condition of pre-PE in pregnant women.
