The expression levels of phosphatidylinositol 3-kinase, protein kinase B and phosphatase and tensin homolog in gliomas
- VernacularTitle:脑胶质瘤中磷脂酰肌醇3-激酶、蛋白激酶B及同源磷酸酶-张力蛋白表达水平
- Author:
Zhenhua SHI
1
;
Wusi QIU
;
Jun CHENG
;
Qizhou JIANG
;
Weimin WANG
;
Zhiyong QIN
Author Information
1. 杭州师范大学附属医院神经外科
- Keywords:
Phosphatidylinositol 3-kinase (PI3K);
Protein kinase B(AKT);
Homologous phosphatase - tensin (PTEN);
Glioma
- From:
China Modern Doctor
2018;56(14):1-3,7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PI3K, AKT and PTEN in gliomas. Methods The pathological specimens of 66 glioma patients who underwent surgery in our hospital and Huashan Hospital from January to December 2017 were analyzed, and another 50 normal pathological specimens were selected as reference group. Immunohisto-chemistry was used to detect the expressions of phosphatidylinositol 3-kinase, protein kinase B and homologous phos-phatase-tensin. The expression of three indicators between glioma tissues and normal brain tissues was compared to analyze the correlation between the three positive expressions in glioma tissues. Results The positive expression rates of PI3K and AKT in normal brain tissue were significantly lower than those in low-grade gliomas and high-grade gliomas, and the difference was significant (P＜0. 05). And the positive expression rates of PI3K and AKT in the low-grade gliomas were significantly lower than those in high-grade gliomas, and the difference was statistically significant (P＜ 0. 05). The positive rate of PTEN protein in normal brain tissue was 100. 0％, which was significantly higher than that in low-grade glioma and high-grade glioma, with significant difference (P＜0. 05). And the positive rate of PTEN protein in the low malignant glioma was significantly higher than that in high grade glioma, and the difference was statistically significant (P＜0. 05). Conclusion PI3K and AKT are highly expressed and PTEN is low-expressed in gliomas, which is related to the degree of malignancy.
