The role and clinical significance of MMP -3/TIMP -1, Th17/Treg in rheumatoid arthritis
- VernacularTitle:MMP-3/TIMP-l、Th17/Treg在类风湿关节炎中的作用及其临床意义
- Author:
Jing CUI
1
;
Xiaoxia WANG
;
Hong WANG
;
Zhenye HAO
;
Yingying GUO
;
Huifang CHEN
;
Jiali HE
Author Information
1. 山西医科大学第二医院风湿免疫科
- Keywords:
Rheumatoid arthritis;
Matrix metalloproteinase 3;
Tissue inhibitor of metalloproteinase -1;
Th17 cells;
Treg cells;
Tumor necrosis factor α antagonist
- From:
China Modern Doctor
2018;56(13):160-163,168
- CountryChina
- Language:Chinese
-
Abstract:
Various studies have shown that the high expression of matrix metalloproteinase-3 (MMP-3) is involved and play an important role in the degradation of the extracellular matrix of synovium, cartilage and subchondral bone of rheumatoid arthritis(RA). Tissue inhibitor of metalloproteinase 1 (TIMP-1) binds specifically to MMP-3 and inhibits the activity of MMP-3. The balance of MMP-3 / TIMP-1 plays an important role in the clinical outcome of RA. New research found that inhibiting Th17 cell differentiation, maintaining Treg (regulatory T cell) activity and regulating Th17/ Treg balance may provide novel targets for the treatment of RA. Further study found that the expression of MMP-3 and Interleukin 17(IL-17) in the peripheral blood of RA patients was significantly increased, the two were positively correlated, and the decrease of Treg could affect the balance of MMP-3/TIMP-1. This article will review the mechanism of MMP-3/TIMP-1 and Th17 /Treg in RA and its clinical significance.
