Effect and efficacy of integrated Chinese and western medicine on intestinal mucosa permeability in the patients with diarrhea after chemotherapy for lung cancer
- VernacularTitle:中西医结合治疗对肺癌化疗后腹泻患者肠黏膜通透性的影响及疗效观察
- Author:
Yi DING
1
;
Haiyue LU
Author Information
1. 浙江省临海市中医院内科
- Keywords:
Lung cancer;
Diarrhea after chemotherapy;
Integrated Chinese and western medicine;
Intestinal mucosal permeability
- From:
China Modern Doctor
2018;56(13):126-128,133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect efficacy of integrated traditional Chinese and western medicine on intestinal mucosal permeability in the patients with diarrhea after chemotherapy for lung cancer. Methods From January 2016 to June 2017, 78 patients with diarrhea after chemotherapy for lung cancer who were treated in the outpatient clinic or during hospitalization were selected, and were randomly divided into integrated Chinese and western medicine group and western medicine group. The patients in the western medicine group were given montmorillonite powder, rehydration (intravenous or oral) to correct water and electrolyte acid-base balance disorders and other western conventional treatments. The integrated Chinese and western medicine group was further given modified Shaoyao Decoction on the basis of the western group. Both groups were given the dosage for 72h. The changes of serum ET, D-lactate and TNF-a before and after treatment were determined and compared between the two groups, and the clinical effect was compared. Results After 72 hours of treatment, the levels of serum ET, D-lactate and TNF-a indices in the two groups were significantly decreased (P＜0. 05 or P＜0. 01). And in the degree of decrease, the integrated Chinese and western medicine group was more significant than the western medicine group (P＜0. 05); at the same time, the total effective rate in the integrated Chinese and western medicine group was higher than that in the western medicine group (χ2=4. 52, P＜ 0. 05). Conclusion Integrated Chinese and western medicine in the treatment of diarrhea after chemotherapy for lung cancer has more positive effects, which can significantly reduce the serum ET, D-lactic acid and TNF-a, and protect the intestinal mucosal barrier to reduce its permeability.
