Clinical value of serum gastric function, Hp detection combined with narrow band imaging magnifying endoscopy in the diagnosis of gastric ulcer
- VernacularTitle:血清胃功能、Hp检测联合窄带成像放大内镜对胃溃疡诊断的临床价值
- Author:
Zhenhua SU
1
;
Liang WANG
;
Sichen WEI
Author Information
1. 河北省沧州市中心医院消化科
- Keywords:
Pepsinogen;
Gastrin;
Helicobacter pylori;
Gastric ulcer
- From:
China Modern Doctor
2018;56(13):37-39,43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of serum gastric function(pepsinogen I, II and PGR, gastrin-17), Helicobacter pylori (Hp) infection combined with narrow-band imaging magnifying endoscopy for the diagnosis of gastric ulcer. Methods From October 2015 to December 2016, we selected 113 patients diagnosed as gastric ulcer and gastric cancer by narrow-band imaging endoscopy (NBI-ME) and diagnosed by pathological examination. 65 patients were divided into gastric ulcer group. 48 patients were divided into gastric cancer group, 65 healthy subjects who had passed the physical examination were selected as the control group. Enzyme-linked immunosorbent assay was used to measure serum gastric function parameters such as serum pepsinogen I / Ⅱ, PGR, and gastrin-17, and C14 breath test was used to detect Hp. Results The Hp infection rate in the gastric ulcer group and the gastric cancer group was significantly higher than that in the control group, the difference was statistically significant (P＜0. 05). Compared with the control group, serum PG I and PGR levels in the gastric ulcer group were significantly increased (P＜0. 05); serum PG I and PGR levels in the gastric cancer group were lower than those in the control group(P＜0. 05). The PGI and PGR levels in the gastric ulcer group were significantly higher than those in the gastric cancer group, the difference was statistically significant (P＜0. 05). Compared with the control group, the serum G-17 concentration in the gastric ulcer group and the gastric cancer group was higher than that in the control group(P＜0. 05). Conclusion PG I, PG Ⅱ, G-17 and other serum gastric functional parameters combined with Hp indicators have been further measured by NBI-ME in gastric ulcer and gastric cancer diagnosis and prognosis has a high reference value.
