Effect of Aidi injection on T lymphocyte subsets and quality of life in patients with colon cancer
- VernacularTitle:艾迪注射液对结肠癌化疗患者T淋巴细胞亚群水平及生活质量的影响
- Author:
Guiyang WU
1
;
Zaiping CHEN
;
Fubo YE
;
Xiongwen ZHU
;
Shichao YUAN
Author Information
1. 浙江省台州市立医院胃肠外科
- Keywords:
Aidi injection;
Colon cancer;
Chemotherapy;
T lymphocyte subsets;
Quality of life
- From:
China Modern Doctor
2018;56(13):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of T lymphocyte subsets and quality of life after administrating Aidi injection in patients with colon cancer. Methods A total of 86 patients with colon cancer admitted to our hospital from February 2015 to May 2017 were enrolled in this study. The patients were divided into chemotherapy group (43 patients, conventional therapy) and combination group (43 cases,conventional chemotherapy+Aidi injection) by random number table. Compared the recent curative effect, level of T lymphocyte subsets, changes of quality of life and adverse reactions before and after treatment. Results There were significant differences in the distribution of CR, PR, SD and PD between the combination group and the chemotherapy group(P＜0. 05). The former had a clinical benefit rate of 72. 09％ and the latter was 51. 16％. The difference was statistically significant(P＜0. 05). There was no significant difference in the level of T lymphocyte subsets and quality of life in the combination group after treatment(P＞0. 05). The CD3+, CD4+, CD4+/CD8+ and scores of quality of life in the chemotherapy group were significantly lower(P＜0. 05) after treatment, CD8+ increased in both groups, and there was statistical difference between the combination group and the chemotherapy group after treatment(P＜0. 05). The incidence of adverse reactions in the combination group was lower than that in the chemotherapy group(P＜0. 05) and the difference of classification comparison was also statistically significant(P＜0. 05). Conclusion The use of Aidi injection in colon cancer patients with chemotherapy can improve the short-term curative effect, avoid the damage of immune function and reduction of the quality of life, and relieve and reduce the adverse reactions caused by chemotherapy.
