Clinicopathological Correlation of Lupus Nephritis.
- Author:
Sun Jin YOU
1
;
Joon Sung PARK
;
Jee Hyun KIM
;
Su Kyoung PARK
;
Sang Cheol BAE
;
Gheun Ho KIM
;
Chong Myung KANG
;
Moon Hyang PARK
;
Chang Hwa LEE
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Korea. changhwa@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Lupus nephritis;
Biochemical marker;
Pathology
- MeSH:
Azotemia;
Biomarkers;
Biopsy;
Creatinine;
Female;
Hematuria;
Humans;
Lupus Nephritis;
Proteinuria;
Retrospective Studies
- From:Korean Journal of Nephrology
2009;28(5):410-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Clinical treatment for lupus nephritis largely depends upon histological renal biopsy classification. But it has been reported that serologic biochemical markers are not strongly associated with pathologic classification. The aim of this study is to see whether serologic markers could predict pathologic class of lupus nephritis for appropriate treatment. METHODS: We investigated 67 patients, who underwent renal biopsy with lupus nephritis at Hanyang University Hospital between January, 2005 and August, 2007. Biological markers for this study are hematuria, proteinuria, serologic data of lupus activity and azotemia. They were retrospectively analyzed from patients grouped by ISN/RPS 2003 lupus nephritis classification. RESULTS: Total 67 patients (men 5, women 62) were enrolled and the mean age of the patients was 30.6+/-9 years. The number of patient group by pathologic classification was 4 cases for class II, 15 cases for class III, 30 cases for class IV and 15 cases for class V. Spot urine protein to creatinine ratio more than 3 increased in class IV group statistically (p=.007). C3 level decreased more in class IV group than class III, V groups. Ten patients showed azotemia, and 9 of them were class IV group (p=.048). CONCLUSION: The patients with more increased proteinuria, decreased C3 level and azotemia showed more frequently in class IV group. Hence those three biological markers may be a clinical clue to pathologic diagnosis.
