Clinicopathological characteristics and immuophenotype analysis of pul-monary sclerosing hemangioma
- VernacularTitle:肺硬化性血管瘤临床病理特征及免疫表型分析
- Author:
Huan WANG
1
;
Qiong CHI
Author Information
1. 浙江省温州市中心医院病理科
- Keywords:
Lung neoplasms;
Pulmonary sclerosing hemangioma;
Clinicopathology;
Immunophenotype;
Histogenesis
- From:
China Modern Doctor
2015;53(35):106-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinicopathological characteristics of pulmonary sclerosing hemangioma(PSH) and to analyze its expression and significance in immunohistochemistry,in order to improve the understanding and diagnostic level of this diesease. Methods The clinicopathological features of 6 patients with PSH in Whenzhou Center Hospital from January 2011 to May 2015 were analyzed.Using immunohistochemical methods,the expression of NapsinA,P63, TTF-1,EMA,CK,Vimentin,SP-B,CgA,Syn,CD34 and MC were observed. Results PSH exhibited the following histo-logical features:papillary,solid,hemorrhagic,sclerotic,and mixed.The majority of tumors showed a mixed pattern of histology. The tumor was composed of two distinct cellular components,the cuboidal or surface cells and the round or polygonal or stroma cells.Immunohistochemical staining revealed the both kinds of cells expressed TTF-1 and EMA,the cuboidal cells expressed NapsinA, P63, CK and SP-B,the round or polygonal cells expressed Vimentin.Neither of these two types of cells expressed MC,CD34 and Syn.Sporadic expression of CgA was observed in one case. Conclusion PSH is a rare lung tumor,with various histologie appearance,and often misdiagnosed as lung cancer. The immunohistochemical detection not only suggested that the tumor originates from the multiple potential of the primary respiratory epithelium, but also had important value in the diagnosis and differential diagnosis of PSH.
