Correlation between sex hormone levels and gender differences and cogni-tive function in patients with schizophrenia
- VernacularTitle:性激素和精神分裂症性别差异及认知功能的相关性研究
- Author:
Jun HUANG
1
;
Qiuping ZHONG
;
Jindong CHEN
;
Dongtao PENG
;
Yan PENG
;
Bo YANG
Author Information
1. 湖南省常德市康复医院精神科
- Keywords:
Schizophrenia;
Sex hormones;
Gender;
Cognitive function
- From:
China Modern Doctor
2015;53(35):77-80,84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the connection between sex hormones and gender differences and cognitive func-tion in patients with schizophrenia. Methods A total of 80 eligible patients including 60 female and 20 male with schizophrenia conducted general information collection and Digit Span Task(DST) and Trial Making Test (TMT) mea-surement. The data o f the schizophrenic patients were collected and analyzed with sex hormones. Results There were significant differences between male and female schizophrenic patients in the age of first onset, course of disease,degree of education and antipsychotic treatment effects(P<0.05). The digit span-forward Task(DSF) score of female patients was higher than that of male patients, TMTA and TMTB were lower than those of male patients (P<0.05). In both male and female schizophrenic patients, E2 level was positively related to the age of first onset, and degree of education, oth-erwise,it was negatively related to the course of disease and antipsychotic treatment effects. In male patients,there was no connection between T level and the age of first onset, course of disease,degree of education and antipsychotic treat-ment effects. The estrogen level of male and female patients was positively correlated with the DSF and was negatively related to the TMTA and TMTB. The testosterone level of male patients was negatively correlated with the TMTand TMTB. Conclusion Estrogen may be related to gender differences in schizophrenia. Estrogen and testosterone have a certain correlation with cognitive function.
