Clinical study of oxidative stress and inflammatory factors in patients with diabetic retinopathy
- VernacularTitle:糖尿病视网膜病变患者氧化应激状态及炎症因子的临床研究
- Author:
Qinghua GUAN
1
;
Jinsong KUANG
;
Lan CHENG
;
Caihong XIN
Author Information
1. 沈阳市第四人民医院内分泌科
- Keywords:
Diabetic retinopathy;
Advanced oxidation protein products;
Vascular endothelial growth factor;
Pigment epithelium-derived factor
- From:
China Modern Doctor
2015;53(35):29-31,38
- CountryChina
- Language:Chinese
-
Abstract:
Objective By measuring the level of serum advanced oxidation protein products (AOPP), vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in patients with diabetic retinopathy (DR), and to explore its possible role in the pathogenesis of DR. Methods 90 type 2 diabetes mellitus (T2DM) patients were divided into three groups:30 patients with non-DR (NDR), 30 patients with back ground-DR (BDR), 30 patients with prolifer-ative-DR (PDR). At the same time, 30 healthy controls were selected. The concentration of serum AOPP was measured by modified Wikto-Sarsat, while VEGF and PEDF by ELISA assay. Results The serum level of AOPP increased gradu ally along with the development of DR, and the difference was statistically significant (P<0.05). Serum levels of VEGF in T2DM groups were significantly increased compared with the control group (P<0.05), and VEGF in BDR and PDR groups were significantly higher than that in NDR group (P<0.05), but the serum level of VEGF in PDR group was sig-nificantly lower than that in BDR group (P<0.05). The serum level of PEDF in each group was gradually decreased, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that the serum level of VEGF was negatively correlated with PEDF(r=-0.734, P<0.05). The serum level of AOPP was positively correlated with VEGF (r=0.816, P<0.05), and negatively correlated with PEDF (r=-0.905, P<0.05). Conclusion The increase of AOPP and VEGF level in serum of patients with diabetes, and the decrease of PEDF may promote the development of DR.
