Investigation of therelationship between HBV antigen variation and the cause of death in HBV-ACLF
- VernacularTitle:乙型肝炎相关慢加急性肝衰竭死因与HBV抗原变异相关性的探讨
- Author:
Caixia YU
1
;
Menghua YANG
;
Caixia WANG
;
Zujiang YU
Author Information
1. 河南省商城县人民医院内三科
- Keywords:
ACLF;
HBV;
Antigen variation;
Survival analysis
- From:
China Modern Doctor
2015;53(35):8-10,14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HBV antigen variationandthe cause of deathin the HBV-related acute-on-chronic liver failure (ACLF). Methods Total of 127 HBV-ACLF patients were divided into survival group and death group, the cause of death, the constitution ratio of mutant rate pre-C region, C gene region and BCP region of two groups were analyzed than before, then MELD and Child-Pugh score system were compared through mul-tivariate Logistic regression analysis to discuss the risk degree of different mutants. Results In 127 cases of HBV-A-CLF patients, 329 mutants were detected between the survival group (n=76) and the death group (n=51). The differ-ences of A1762T/G1764A, G1896A and L60V were significant in the death group than in the survival group according to the results of multivariate Logistic regression analysis (P<0.05), and the scores of MELD were significant difference than the scores of Child-Pugh in the two groups(P<0.05). Conclusion The mutants of A1762T/G1764A, G1896A and L60V in HBV-ACLF are independent risk factors lead to its death, MELD score over matches Child-Pugh score,and MELD score for judging the prognosis and outcome of HBV-ACLF has important significance.
