Effects of Xingnaojing injection on plasma MMP-9 and TIMP-1 for pa-tients with cerebral hemorrhage
- VernacularTitle:醒脑静注射液对脑出血患者血浆MMP-9及TIMP-1的影响
- Author:
Lingxiu JIANG
1
;
Yu LIANG
;
Wenwu CHEN
;
Mengzhou XUE
Author Information
1. 河南大学第一附属医院神经内科
- Keywords:
Xingnaojing;
Cerebral hemorrhage;
Matrix metalloproteinase (MMP-9);
Tissue inhibitor of metalloproteinase (TIMP)
- From:
China Modern Doctor
2015;53(35):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Xingnaojing injection on plasma MMP-9 and TIMP-1 levels for patients with cerebral hemorrhage. Methods A total of 60 patients with acute cerebral hemorrhage from February 2014 to May 2015 were selected as research subjects and randomly divided into the research group and the control group, with 30 patients in each group. The research group was given Xingnaojing injection on the basis of regular treatment, and the control group was given regular treatment. The plasma MMP-9 and TIMP-1 levels of the two groups of patients were compared, and the correlation between MMP-9 and TIMP-1 levels in the patients and their correlation with cere-bral edema were analyzed. Results On the fifth day of onset of the disease in the two groups of patients, MMP-9 and TIMP-1 levels were significantly increased, and the levels were reduced on the 14th day. On the fifth day and 14th day of onset of the disease in the research group, MMP-9 level was significantly lower than that in the control group, and TIMP-1 level was significantly higher than that in the control group. The differences were statistically significant (P<0.01). In 24 h, the volume of cerebral edema in the two groups was positively correlated to MMP-9 (r=0.682, P=0.761), and was significantly negatively correlated to TIMP-1(r=-0.489, P=-0.619); on the 14th day, the volume of cerebral edema was positively correlated to MMP-9 (r=0.516, P=0.835). Conclusion Xingnaojing is able to significantly reduce the increasing degree of MMP-1 in the patients with cerebral hemorrhage, enhance the increasing degree of TIMP-1, and improve patients' cerebral edema.
