Effects of parecoxib sodium on emergence agitation for patients with liver cancer under sevoflurane anesthesia
- VernacularTitle:帕瑞昔布钠对肝癌患者七氟醚麻醉苏醒期躁动的影响
- Author:
Ping FANG
1
;
Qingcao LI
;
Lihong HU
;
Jingyu WANG
;
Hong YE
Author Information
1. 宁波市医疗中心李惠利医院麻醉科
- Keywords:
Parecoxib;
Sevoflurane;
Liver cancer;
Emergence;
Agitation
- From:
China Modern Doctor
2015;(22):109-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of parecoxib sodium on emergence agitation for patients with liver cancer under sevoflurane anesthesia. Methods A total of 76 patients received liver cancer surgery under sevoflurane anesthesia. Among them, 38 patients were assigned to the parecoxib group (P group), and the other 38 patients were assigned to the control group (C group). P group and C group were given intravenous injection of 40 mg of parecoxib and 10 μg of sevoflurane respectively 30 min before the completion of the surgery. The vital signs were observed 15 min and 30 min after the extubation, pain VAS score and agitation RS score were calculated 15 min after the extubation, and at the same time, patients' adverse effects such as nausea and vomiting, drowsiness and respiratory depression were observed. Results General data such as age, weight, height, surgery time, incision length and VAS scores between the two groups of patients were not statistically significant(P>0.05); RS scores, and incidence rate of nausea, vomiting, and drowsiness in P group were significantly lower than those in C group, and the differences were statistically significant (P<0.05);during emergence, the two groups of patients showed stable vital signs without respiratory depression. All drainage tubes were unobstructed without being compressed or distorted. Conclusion Parecoxib is effective in reducing the agi-tation of patients with liver cancer during the emergence of sevoflurane anesthesia.
