Living donor liver transplantation for patients with alcoholic liver disease.
10.14701/kjhbps.2013.17.1.14
- Author:
Yo Han PARK
1
;
Shin HWANG
;
Chul Soo AHN
;
Ki Hun KIM
;
Deok Bog MOON
;
Tae Yong HA
;
Gi Won SONG
;
Dong Hwan JUNG
;
Gil Chun PARK
;
Jung Man NAMGOONG
;
Hyung Woo PARK
;
Chun Soo PARK
;
Sung Hwa KANG
;
Bo Hyeon JUNG
;
Sung Gyu LEE
Author Information
1. Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. shwang@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Living donor liver transplantation;
Alcoholic liver disease;
Relapse
- MeSH:
Alcoholics;
Biomarkers;
Body Weight;
Hepatitis B;
Hepatitis B Surface Antigens;
Humans;
Liver;
Liver Diseases;
Liver Diseases, Alcoholic;
Liver Transplantation;
Living Donors;
Recurrence;
Risk Factors;
Survival Rate;
Tissue Donors;
Transplants
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2013;17(1):14-20
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUNDS/AIMS: Since most transplantation studies for alcoholic liver disease (ALD) were performed on deceased donor liver transplantation, little was known following living donor liver transplantation (LDLT). METHODS: The clinical outcome of 18 ALD patients who underwent LDLT from Febraury 1997 to December 2004 in a large-volume liver transplantation center was assessed retrospectively. RESULTS: The model for end-stage liver disease score was 23+/-11, and mean pretransplant abstinence period was 16+/-13 months, with 14 (77.8%) patients being abstinent for at least 6 months. Graft types were right lobe grafts in 11, left lobe grafts in 2 and dual grafts in 5. Graft to recipient body weight ratio was 0.94+/-0.16. The relapse rates in patients who did and did not maintain 6 months of abstinence were 7.1% and 50%, respectively (p=0.097). Younger recipient age was a significant risk factor for alcohol relapse (p=0.027). Five recipients with antibody to hepatitis B surface antigen (HBsAg) received core antibody-positive liver graft, but two of them showed positive HBsAg seroconversion. Overall 5-year patient survival rate following LDLT was 87.8%, with a 5-year relapse rate of 16.7%. CONCLUSIONS: Pretransplant abstinence for 6 months appears to be benefical for preventing posttransplant relapse. Life-long prophylactic measure should be followed after use of anti-HBc-positive liver grafts regardless of hepatitis B viral marker status of the recipient.
