Study of effectiveness and safety of tranexamic acid in reducing blood loss and blood transfusion rate of elderly hip fracture surgery
- VernacularTitle:氨甲环酸减少老年髋部骨折手术失血量与输血率的有效性及安全性研究
- Author:
Mingxin YANG
1
;
Hua YU
;
Jinhong ZHAO
;
Jie SU
Author Information
1. 四川省长宁县人民医院骨科
- Keywords:
Tranexamic acid;
Hip fractures;
Hemiarthroplasty;
Blood loss;
Blood transfusion
- From:
China Modern Doctor
2015;(22):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effectiveness and safety of preoperative intravenous administration of tranex-amic acid in the hemiarthroplasty treatment of elderly hip fracture. Methods Seventy patients who received hemiarthro-plasty due to femoral neck fracture (Garden Ⅲ/Ⅳ) in our hospital from January 2008 to December 2012 were analyzed retrospectively, of which 35 patients were given preoperative intravenous administration of tranexamic acid and 35 pa-tients were not. The patients'preoperative and postoperative hemoglobin and hematocrit values were collected. The to-tal blood loss amount was calculated through Gross equation and the postoperative drainage amount, number of people receiving blood transfusion, blood transfusion amount and occurrence of thrombus events were recorded. Results The total blood loss amount of the tranexamic acid group was (867.79±76.93) mL, which was significantly lower than (1207.07±403.83) mL of the control group, with statistically significant difference(P=0.036). The postoperative drainage amount was (305.67±103.68) mL, which was lower than the (393.00±66.29) mL of the control group, with statistically significant difference (P<0.01). The application of tranexamic acid decreased the blood transfusion rate from 42.86% to 20.00%(P=0.039). The complications of postoperative thrombus events did not increase (P=0.643). Conclusion In the treatment of elderly femoral neck fracture, the preoperative intravenous administration of tranexamic acid can effec-tively and safely reduce the blood loss amount and blood transfusion rate of hemiarthroplasty.
