Study on the relationship between HBV genotype distribution and clinical characteristics in Hangzhou area
- VernacularTitle:杭州地区乙型肝炎病毒基因分型与临床指标关系研究
- Author:
Yanmin CHEN
1
;
Wufeng YUAN
;
Zhenzhen PANG
Author Information
1. 浙江省人民医院检验中心
- Keywords:
Hepatitis B virus;
Genotype;
Clinical characteristics
- From:
China Modern Doctor
2015;(21):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of HBV genotypes and the relationship between HBV genotypes and the clinical characteristics in Hangzhou area. Methods The genotype, content of HBV-DNA, serological indicators and AFP were detected by RT-PCR, time resolved immunofluorescence method respectively in 146 cases of HBV-DNA positive patients. The relationship between HBV genotype and the clinical characteristics were analyzed by the statistical analysis.Results In the HBV genotyping, there were 75 cases of type B (51.4%),62 cases of type C (42.5%),9 cases of no B or no C type (6.2%);In type C, the HBV-DNA, HbsAg and HbeAg content were significantly higher than the type B.The content of AFP in type C was higher than type B, but with no statistical difference(P>0.05). Conclusion In Hangzhou area, the priority genotype of HBV is type B. Genotype has a certain relationship with the clinical character-istics and the severity of the disease.
