The inhibitory effects of sorafenib on gastric cancer cells MGC80-3
- VernacularTitle:索拉非尼对胃癌细胞MGC80-3抑制作用实验研究
- Author:
Yi CHEN
1
;
Shuo CHEN
;
Juanhong ZHENG
;
Yaxin ZHAO
;
Jie JIA
Author Information
1. 浙江省温州市中西医结合医院消化内科
- Keywords:
Gastric cancer cell;
Sorafenib;
Apoptosis;
Proliferation
- From:
China Modern Doctor
2015;(21):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the inhibitory effective and mechanism on the proliferation and apoptosis of sorafenib in vitro gastric cancer MGC80-3 cells. Methods The inhibitory effective of sorafenib at different concentrations for gastric cancer cell MGC80-3 were analyzed by MTT assay. Apoptosis rate was observed by AnnexinV/PI staining. Re-sults The proliferation inhibition of sorafenib on gastric cancer MGC80-3 cell was time-dose dependent manner, the difference was statistically significant (P<0.05). Conclusion The apoptosis of gastric cancer MGC80-3 cells is different and the apoptotic rate is increased with the increase of sorafenib concentration.
