Variation of vascular endothelial growth factor in diabetics with asymp-tomatic and symptomatic peripheral artery disease
- VernacularTitle:隐匿性与症状性糖尿病下肢血管病变患者血管内皮生长因子的变化
- Author:
Luobing TIAN
1
;
Jiangyuan QIN
;
Hui FANG
;
Guyue ZHANG
;
Aiyuan WANG
;
Xueling SUN
;
Bing LI
Author Information
1. 河北省唐山市工人医院内分泌二科
- Keywords:
Vascular endothelial growth factor;
Diabetes mellitus;
Asymptomatic peripheral artery disease;
Symptomatic peripheral artery disease
- From:
China Modern Doctor
2015;(19):87-89,92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the serum level of vascular endothelial growth factor (VEGF) of the patients with asymptomatic and symptomatic peripheral artery disease (PAD) in diabetics for providing evidence for screening the patients with PAD early. Methods Selected the study population including diabetics without PAD(90 cases),diabetics with asymptomatic PAD patients(93 cases)and diabetics with symptomatic PAD patients(92 cases). The level of serum VEGF was measured using enzyme linked immunosorbent assay(ELISA) and analyzed in the three groups. The varia-tion of serum VEGF was further analyzed in the three groups excluding the diabetic retinopathy in the stratified analysis. Results The serum level of VEGF with asymptomatic and symptomatic PAD in diabetics were increased,compared with the diabetics without PAD (P<0.05). Excluding the patients with diabetic retinopathy, the serum level of VEGF of the patients with asymptomatic and symptomatic PAD in diabet ics was still increased, compared with the dia betics without PAD (P<0.05). The serum level of VEGF level was significantly positively associated with HbA1c in the pa-tients with asymptomatic and symptomatic PAD in diabetics (r=0.267, 0.352, P all<0.05). Conclusion The level of serum VEGF in the patients with asymptomatic and symptomatic PAD in diabetics had been significantly increased.
