Prognostic Significance of Ki-67 Expression in Rectal Carcinoid Tumors.
- Author:
Su Min HONG
1
;
You Sun KIM
;
Jung Seop MOON
;
Jin Nam KIM
;
Myoung Ki OH
;
Sun Ok KWON
;
Seong Yeon JEONG
;
Seong Woo HONG
;
Yun Kyung KANG
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Rectum; Carcinoid tumor; Ki-67; Endoscopy; Therapeutics
- MeSH: Adult; Age Factors; Aged; Carcinoid Tumor/*diagnosis/metabolism/pathology; Colonoscopy; Female; Humans; Immunohistochemistry; Ki-67 Antigen/*metabolism; Male; Middle Aged; Prognosis; Rectal Neoplasms/*diagnosis/metabolism/pathology; Retrospective Studies; Sex Factors
- From:The Korean Journal of Gastroenterology 2013;61(2):82-87
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. METHODS: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. RESULTS: The mean age (+/-SD) of the patients was 56.3+/-10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5+/-0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7+/-1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4+/-25.4 months, and no recurrences were observed. CONCLUSIONS: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
